Clemson vs. Louisville Pick Prediction 11/6/2021 by Tony T.
Clemson at Louisville—Clemson has failed to cover seven of eight. Tigers against the ACC averaging 19.7 points and 323 yards. Quarterback D.J. Uiagalelei completing only 55.7% of his throws. He is throwing for only 4.9 per pass attempt against the conference. Louisville offense trending better. Past three games Cardinals averaging 458 yards with 259 rushing for 6.4 per rush. Quarterback Malik Cunningham averaging 8.7 yards per pass attempt against the ACC. He is also threat to run with an average of 104.5 yards per game past two games. Louisville has defended better at home holding teams to 360 yards with 3.9 yards per rush and 6.3 per pass attempt. Play Louisville +4.