Arizona Cardinals vs. San Francisco 49ers Pick Prediction 11/7/2021 by Tony T.
Cardinals at 49ers—Good news for San Francisco as late word on Saturday night is that both Samuel and Mitchell will play. Cardinals dealing with injuries to Kyler Murray and DeAndre Hopkins as they are both questionable. Media reports have both players as game time decisions. A.J. Green will not play after a COVID positive test. These are impact players for the Cardinals. San Francisco coming off a good performance in an eleven point win at Chicago with 467 offensive yards. 49ers offense trending well past three games with 5.2 yards per rush and 8.1 yards per pass attempt. Play San Francisco -3.