Buffalo Bills vs. New Orleans Saints Pick Prediction 11/25/2021 by Tony T.
Bills at Saints—New Orleans again will be without running back Alvin Kamara to injury. Backup Mark Ingram is questionable with a knee injury. New Orleans starting left tackle is out and right tackle questionable. Defensive end Marcus Davenport out. Bills have been quite the bounce back team following a loss. Following their first three losses the Bills responded with wins by 35 at Miami, 15 at Miami and 28 at the Jets. Saints are also without quarterback Jameis Winston so it is Trevor Siemian under center. They carry a three game losing streak into this game. Siemian started all three games completing only 58.8% for 6.5 yards per pass attempt. Bills defense trending well past three games allowing 318 yards, 4.3 yards per rush and 5.7 per pass attempt. Play Buffalo -6.5.