In this episode, Alex and I discuss Derrick Henry's foot injury, three back-up quarterbacks winning, and an Eagles-Lions rant. First, we talk about the NFL's best running back - Derrick Henry. During Sunday's win over the Colts, Henry injured his foot. He is likely to miss several weeks. We both believe Tennessee can withstand the loss of its franchise rusher with a grip of the AFC South. We also believe the Titans will depend more on A.J. Brown's receiving and Ryan Tannehill throwing. Then, we look at three back-up quarterbacks who won on Sunday. We first start with Cooper Rush leading the Dallas Cowboys to a road win over the Minnesota Vikings. We talk about how Rush outplayed veteran Kirk Cousins in his first NFL start. We also talk about the Cooper Rush to Amari Cooper connection for the game-winning touchdown. Then, we talk about Mike White leading the New York Jets to a win over the Cincinnati Bengals. We talk about White throwing for over 400 yards and how NY beat Joe Burrow and an explosive Bengals offense. We also look at Jets rookie running back Michael Carter coming onto the NFL landscape with 172 total yards and a touchdown in the win. We also discuss Saints quarterback Trevor Siemian coming off the bench to lead New Orleans in an NFC South clash with Tom Brady's Tampa Bay Bucs. Siemian, who replaced Jameis Winston after sustaining a season-ending knee injury, played steady football while Brady and the Bucs committed too many penalties and turnovers. Finally, The Big D rants after a frustrating Eagles-Lions game for fantasy and DFS owners.