12/1/24 San Francisco 49ers vs. Buffalo Bill FREE NFL Week 13 Pick Against the Spread


12/1/24 San Francisco 49ers vs. Buffalo Bill FREE NFL Week 13 Pick Against the Spread


San Francisco 49ers vs. Buffalo Bills NFL Pick Prediction 12/1/2024 by Tony T.

49ers at Bills Injuries

San Francisco quarterback Brock Purdy is questionable with their left tackle and guard out. On defense a tackle, end and nickel back are out with a linebacker questionable. Buffalo tight end Kincaid is out with receiver Coleman questionable. On defense a linebacker is questionable.

Recent Box Score Key Stats

49ers at Bills 8:20PM ET—San Francisco drops to 5-6 after their 38-10 road defeat at Green Bay. The 49ers posted 241 yards with 44 rushing for 2.8 yards a carry. On defense they allowed 324 yards to the Packers with 169 rushing for 4 yards a carry. Brandon Allen completed 17 of 29 for 199 yards with a touchdown and pick. Buffalo sits at 9-2 with their 30-21 home win to Kansas City. The Bills produced 366 yards with 104 rushing for 3.4 yards a carry. Defensively they allowed 259 yards to the Chiefs with 181 passing on 33 attempts. Josh Allen went 27 of 40 for 262 yards with a touchdown and interception.