Denver Broncos vs. San Francisco 49ers NFL Pick Prediction 8/9/2025 by Tony T.
Broncos at 49ers Injuries
Denver offense healthy. A starting inside linebacker is questionable as is a backup. The secondary is healthy. SF quarterback Kurtis Rouke is out. They are banged up at running back and receiver. SF has several injuries on the defensive line and secondary with a healthy linebacker group.
Recent Box Score Key Stats
Broncos at 49ers 8:30PM ET—San Francisco is not expected to play their starters. Denver will play starters in their preseason opener. Backup Mac Jones is expected to start at quarterback for the 49ers. Bo Nix will start at quarterback for the Broncos.