LA Chargers vs. San Francisco 49ers NFL Pick Prediction 8/16/2025 by Tony T.
Chargers vs. 49ers Injuries
LA is dealing with injuries at receivers. They are healthy on defense. Mac Jones and Kurtis Rourke are banged up at quarterback. Several receivers are on the injury report on the depth chart. Both starting guards are questionable. Cluster injuries defensively on the line and secondary.
Recent Box Score Key Stats
Chargers at 49ers 8:30PM ET—LAR fell to 2-1 in the preseason with their 23-22 defeat to the Rams. Trey Lance went 7 of 15 for 121 yards. There is battle with Taylor Heinicke for the backup job. San Francisco moved to 1-1 in the preseason after their 22-19 win at Las Vegas. Brock Purdy saw action and targeted Ricky Pearsall in his outing.