San Francisco 49ers vs. Seattle Seahawks NFL Pick Prediction 9/7/2025 by Tony T.
49ers at Seahawks Injuries
San Francisco running back Christian McCaffrey is questionable. Seattle starters are healthy. Seattle has a significant injury advantage based on the number of players on injured reserve.
Recent Box Score Key Stats
49ers at Seahawks 4PM ET—San Francisco finished at 6-11 last year for head coach Kyle Shanahan in his ninth season. Traded was Deebo Samuel and Brandon Ayuk is on the PUP list. San Francisco despite their injuries still rushed for 4.7 yards a carry and threw for 8.3 yards per pass attempt. Turnovers were a problem. On defense they limited foes to 4.4 yards per run and 6.4 yards per pass attempt. Seattle sat 10-7 last year for head coach Mike McDonald in his second year. Sam Darnold comes over from Minnesota and Geno Smith is now a Raider. The Seahawks got efficient play at quarterback last year. The defense held opponents to 6.3 yards per pass attempt.