San Francisco 49ers vs. New Orleans Saints NFL Pick Prediction 9/14/2025 by Tony T.
49ers at Saints Injuries
Purdy and Kittle are out for San Francisco. Receiver Jennings and a left tackle Williams are questionable. New Orleans left guard is out with their right tackle questionable. On defense a linebacker is out. New Orleans has a significant injury advantage based on the Chao ratings by +5.80. Both offenses have low ratings.
Recent Box Score Key Stats
49ers at Saints 1PM ET—San Francisco is 1-0 as they defeated Seattle 17-13 on the road. The 49ers rushed for only 3.3 yards per carry, but a late drive was carried by the passing game for the win. They stymied the Seahawks offense for 3.2 yards a carry and ineffective passing. Brock Purdy was 26 of 35 for 277 yards with two touchdowns and two picks. But with his turf toe he gives way to Mac Jones. New Orleans is 0-1 with their 20-13 home defeat to Arizona. The rushing game produced 4.9 yards a carry but poor work in the passing game. They allowed 5.4 yards per run to the Cardinals and did a good job defending the pass by allowing 5 yards per attempt. Spencer Rattler was 27 of 46 for 214 yards.