Indianapolis vs. Tennessee NFL Pick Prediction 9/21/2025 by Tony T.
Indianapolis vs. Tennessee Injuries
Indianapolis has healthy starters. The Titans right tackle is out with right guard questionable. Tennessee has a nose tackle out with both corners questionable. Indianapolis has a clear injury advantage based on Chao ratings of +4.90. Tennessee has low health ratings on offense and defense.
Recent Box Score Key Stats
Colts at Titans 1PM ET—Indianapolis is 2-0 following their 29-28 home victory against Denver. The Colts had a strong offensive performance on both sides. They rushed for 167 yards for 5.2 yards a carry. On defense they did allow 4.9 yards a carry to the Broncos with 6.8 yards per pass attempt. Daniel Jones hit 23 of 34 for 316 yards and a touchdown. He had a rushing touchdown. Tennessee is 0-2 with their 33-19 home defeat to LA Rams. Titans were up three at the half then outscored 23-6 in the second half. Titans rushed for about four yards a carry but inefficient in the passing game. They allowed 149 yards rushing to the Rams for six yards a carry with 290 yards passing for 8.8 yards per pass attempt. Cam Ward hit 19 of 33 for 175 yards with a touchdown.