Denver Broncos vs. LA Chargers NFL Pick Prediction 9/21/2025 by Tony T
Broncos vs. Chargers Injuries
Denver tight end Engram is out. LA lost their left tackle for the season with a tight end Dissly out. On defense a linebacker and corner are questionable. Denver has a significant injury advantage based on the Dr Chao ratings by +4.80.
Recent Box Score Key Stats
Broncos at Chargers 4PM ET—Denver is 1-1 following their29-28 road defeat to Indianapolis. The Broncos rushed for nearly five yards a carry and effective in the passing game. They allowed 167 yards rushing to the Colts for 5.2 yards a carry with 306 yards passing for 9 yards per pass attempt. Bo Nix hit 22 of 30 for 206 yards with three touchdowns and a pick. LA is 2-0 after their 20-9 road win at Las Vegas on Monday night. The Chargers rushed for 81 yards for 3.1 yards a carry with effective passing. They limited the Raiders to 68 yards rushing with 150 passing for 3.5 yards per pass attempt. Justin Herbert completed 19 of 27 for 242 yards with two touchdowns.