Arizona Cardinals vs. San Francisco 49ers NFL Pick Prediction 9/21/2025 by Tony T.
Cardinals at 49ers Injuries
Arizona left tackle is questionable. On defense a corner is doubtful and corner questionable. San Francisco quarter Purdy, receiver Jennings and left tackle questionable. Arizona has a clear injury advantage based on the Chao ratings.
Recent Box Score Key Stats
Cardinals at 49ers 4:25PM ET—Arizona is 2-0 following their 27-22 home victory against Carolina. The Cardinals rushed for under four yards a carry with pedestrian passing. They limited the Panthers to 49 rushing yards with high volume pass attempts for only 5.5 yards per pass attempt. Kyler Murray hit 17 of 25 for 220 yards with a touchdown and pick. He rushed for 32 yards. San Francisco is 2-0 after their 2-21 road win at New Orleans. The 49ers rushed for only 77 yards and moved the football through the air. They held the Saints to four yards a carry with 5.5 yards per pass attempt. Brock Purdy missed the game and is unlikely to play on Sunday. Mac Jones hit 26 of 39 for 279 yards and three touchdowns.