Kansas City Chiefs vs. NY Giants NFL Pick Prediction 9/21/2025 by Tony T.
Chiefs at Giants Injuries
KC receivers Worthy and Rice are out. On defense a defensive end is out. NY left tackle is questionable. On defense a linebacker is out and end doubtful. No injury advantage based on the Chao ratings.
Recent Box Score Key Stats
Chiefs at Giants 8:20PM ET— KC is 0-2 following their 20-17 home defeat to Philadelphia. The Chiefs rushed for 121 yards for 4.7 yards a carry and inefficient passing. Defensively they held the Eagles to 94 yards passing with 3.6 yards per run. Patrick Mahomes hit 16 of 29 for 187 yards with a touchdown and pick. He had 66 yards rushing with a touchdown. NY is 0-2 following their 40-37 road defeat at Dallas. The Giants rushed for four yards a carry with strong passing numbers. They allowed 4.8 yards per rush to the Cowboys with 343 yards passing for 6.6 yards per pass attempt. Russell Wilson hit 30 of 41 for 450 yards with three touchdowns and a pick.