9/28/25 LA Chargers vs. New York Giants NFL Picks Week 4


9/28/25 LA Chargers vs. New York Giants NFL Picks Week 4


LA Chargers vs. NY Giants NFL Pick Prediction 9/28/2025

Chargers vs. Giants Injuries by Tony T.

LA tight end Dissly and right guard are out. Their center is questionable. New York has a defensive end doubtful. The Giants have an injury edge based on the chao ratings by +3.80 ratings points.

Recent Box Score Key Stats

Chargers at Giants 1PM ET—LA is 3-0 with their 23-20 home victory against Denver. LA rushed for 3.8 yards a carry and effective in the passing game. They limited the Broncos passing game and allowed 118 yards rushing for 5.6 yards a carry. Justin Herbert hit 28 of 47 for 300 yards with a touchdown and pick. NY is 0-3 following their 22-9 home defeat to Kansas City. The Giants rushed for 130 yards for 4.8 yards a carry and were ineffective in the passing game. They held KC to under four yards a carry with only 5.4 yards per pass attempt. Jaxson Dart makes his NFL debut at quarterback taking over for an ineffective Russell Wilson.