New Orleans Saints vs. Buffalo Bills NFL Pick Prediction 9/28/2025 by Tony T.
Saints at Bills Injuries
New Orleans has a linebacker out. Buffalo right tackle is questionable. On defense a tackle and linebacker are out. New Orleans has an injury advantage based on the Chao ratings by +3.10 ratings. Buffalo has a low health rating on defense at 77.6.
Recent Box Score Key Stats
Saints at Bills 1PM ET—New Orleans is 0-3 following their 44-13 road defeat to Seattle. The Saints rushed for three yards a carry and performed poorly in the passing game. They limited the Seahawks on the ground but allowed 233 yards rushing for 11.1 yards per pass attempt. Spencer Rattler completed 28 of 39 for 218 yards with a touchdown and pick. Buffalo improved to 3-0 after their 31-21 home victory to Miami. The Bills rushed effectively with 157 yards for 5.8 yards a carry. They allowed 130 yards rushing to the Dolphins for 5.2 yards a carry but only 4.3 yards per pass attempt. Josh Allen hit 22 of 28 for 213 yards and three touchdowns.