Jacksonville Jaguars vs. San Francisco Giants NFL Pick Prediction 9/28/2025 by Tony T.
Jaguars vs. Giants Injuries
Jacksonville receiver Brown is questionable. San Francisco receivers Jennings, Pearsall and guard are questionable. Receivers Ayuk, Taylor and Watkins are out. Tight end Kittle is out. SF defensive end is out with cornerback questionable. Jacksonville has a massive injury advantage based on the Chao ratings by +14.3. SF defense has a low 74.8 injury rating. Jacksonville have healthy ratings on both units over 92.
Recent Box Score Key Stats
Jaguars at 49ers 4PM ET—Jacksonville improved to 2-1 with their 17-10 home victory to Houston. The defense led the Jags to victory holding the Texans to 87 rushing yards with 4.8 yards per pass attempt. Jacksonville rushed for 3.6 yards a carry and was ineffective in the passing game. Trevor Lawrence hit 20 of 40 for 222 yards and a pick. San Francisco is 3-0 after their 16-15 home victory against Arizona. SF rushed for 3.4 yards a carry and effectively moved the football through the air with a backup QB. They limited the Cardinals on the ground and allowed 154 yards passing for 4.4 yards per pass attempt. Brock Purdy was dealing with a toe injury and missed the past two games. He is expected to return on Sunday.