Indianapolis Colts vs. LA Rams NFL Pick Prediction 9/28/2025 by Tony T.
Colts vs. Rams Injuries
Indianapolis receiver Pierce and right guard are out. On defense nickel back is out with tackle questionable. LA receiver Adams, tight end Higbee and right tackle are questionable. No significant injury advantage based on the Chao ratings.
Recent Box Score Key Stats
Colts at Rams 4PM ET—Indianapolis improved to 3-0 following their 41-20 road win at Tennessee. The Colts rushed for 137 yards for 4.9 yards a carry and threw the football efficiently. They limited the Titans on the ground and held them to 5.1 yards per pass attempt. Daniel Jones completed 18 of 25 for 228 yards and a touchdown. LA fell to 2-1 with their 33-26 road defeat to Philadelphia. LA rushed for 5.2 yards a carry but were inefficient in the passing game. They limited the Eagles ground attack and allowed 6.3 yards per pass attempt. Matthew Stafford was 19 of 33 for 196 yards with two touchdowns and a pick.