Atlanta Falcons vs. San Francisco 49ers NFL Pick Prediction 10/19/2025 by Tony T.
Falcons vs. 49ers Injuries
Atlanta receiver Mooney and left tackle are questionable. Their nickel back is out. San Francisco quarterback Purdy and receiver Pearsall are out. On defense Bosa is out with a corner and nickel back are questionable. Atlanta has a significant injury advantage based on the Chao ratings. San Francisco defense has the lowest health rating at 65.3 based on players on IR.
Recent Box Score Key Stats
Falcons at 49ers 8:20 PM ET—Atlanta improved to 3-2 following their 24-14 home victory against Buffalo on Monday night. The Falcons gained 443 yards with effective passing and throwing. They limited the Bills passing attack and allowed 134 yards rushing for 5.6 yards per run. Michael Penix completed 20 of 32 for 250 yards and a touchdown. San Francisco is 4-2 after their 30-19 road defeat at Tampa Bay. The 49ers rushed for three yards a carry and moved the ball through the air. They allowed four yards per rush to the Bucs with 248 yards passing for 10.8 yards per pass attempt. Mac Jones hit 27 of 39 for 347 yards but two interceptions.