Louisville vs. SMU College Football Pick Prediction 11/22/2025 by Tony T.
Recent Box Score Key Stats
Louisville at SMU 12PM ET—Louisville fell to 7-3 following their 20-19 home defeat to Clemson. The Cardinals had movement through the air and rushed for 171 yards for 5.7 yards per carry. On defense they allowed four yards per run with 187 yards passing for 5.5 yards per pass attempt.