12/21/25 Tampa Bay Buccaneers vs. Carolina Panthers NFL Picks Week 16


12/21/25 Tampa Bay Buccaneers vs. Carolina Panthers NFL Picks Week 16


Tampa Bay Buccaneers vs. Carolina Panthers NFL Pick Prediction 12/21/2025 by Tony T.

Buccaneers vs. Panthers Injuries

Tampa Bay starters are healthy on offense and defense. Carolina left tackle is questionable. On defense an end and linebacker are out. There is no significant injury advantage based on the Chao rating.

Recent Box Score Key Stats

Buccaneers at Panthers 1PM ET—Tampa Bay fell to fell to 7-7 following their 29-28 home defeat against Atlanta. Buccaneers had movement in the passing game and rushed for 88 yards for 4 yards a carry. On defense they allowed 5.3 yards per run with 365 yards passing for 8.3 yards per pass attempt. Baker Mayfield completed 19 of 34 for 277 yards with two touchdowns and an interception. Carolina drops to 7-7 with their 20-17 road defeat against New Orleans. Panthers were inefficient in the passing game and rushed for 127 yards for 4.1 yards a carry. On defense they allowed 3.2 yards per run with 256 yards passing for 7.8 yards per pass attempt. Bryce Young hit 15 of 24 for 163 yards and a touchdown.