12/21/25 Kansas City Chiefs vs. Tennessee Titans NFL Picks Week 16


12/21/25 Kansas City Chiefs vs. Tennessee Titans NFL Picks Week 16


Kansas City Chiefs vs. Tennessee Titans NFL Pick Prediction 12/21/2025 by Tony T.

Chiefs vs. Titans Injuries

KC quarterback Mahomes, receiver Rice and right tackle are out. On defense, a tackle and corner are out. Tennessee receiver Jefferson, tight end Helm and right guard are questionable. On defense a linebacker is out with a linebacker and corner questionable. Tennessee has a clear injury advantage based on Dr Chao ratings by +8.80. KC offense has the lowest health rating at 66.1.

Recent Box Score Key Stats

Chiefs at Titans 1PM ET—Kansas City fell to 6-8 following their 16-13 home defeat against LA Chargers. Chiefs had some movement in the passing game and rushed for only 49 yards for 2.3 yards a carry. On defense they held LA to 3.2 yards per run with 201 yards passing for 6.9 yards per pass attempt. Patrick Mahomes is out for the season. Gardner Minshew will start. Mishaw played in ten games last year with 66.3% completion rate for 6.6 yards per pass attempt. Tennessee fell to 2-11 after their 37-24 road defeat against San Francisco. Titans had light movement in the passing game and rushed for 136 yards for 6.8 yards per pass attempt. Cam Ward hit 18 of 29 for 170 yards and two touchdowns.