12/21/25 Atlanta Falcons vs. Arizona Cardinals NFL Picks Week 16


12/21/25 Atlanta Falcons vs. Arizona Cardinals NFL Picks Week 16


Atlanta Falcons vs. Arizona Cardinals NFL Pick Prediction 12/21/2025 by Tony T.

Falcons vs. Cardinals Injuries

Atlanta receiver London is questionable and on defense a corner is out. Arizona left tackle and left guard are out. Receiver Harrison Jr. and receiver Weaver is questionable. Atlanta has a significant injury advantage based on the Chao ratings. Arizona offense has the lowest health rating at 56.1 with the Falcons defense the highest rating at 85.1.

Recent Box Score Key Stats

Falcons at Cardinals 4PM ET—Atlanta improved to 5-9 following their 29-28 road victory against Tampa Bay. Falcons had a good passing performance and rushed for 111 yards for 5.3 yards a carry. On defense they allowed four yards per run with 250 yards passing for 7.4 yards per pass attempt. Kirk Cousins completed 30 of 44 for 373 yards with three touchdowns. Arizona drops to 3-11 with their 40-20 road defeat against Houston. Cardinals had some movement throwing the football and rushed for 72 yards for 3.4 yards per run. On defense they allowed 399 yards with poor work against the run and pass. Jacoby Brissett hit 27 of 40 for 249 yards with three touchdowns and a pick.