12/21/25 Jacksonville Jaguars vs. Denver Broncos NFL Picks Week 16


12/21/25 Jacksonville Jaguars vs. Denver Broncos NFL Picks Week 16


Jacksonville Jaguars vs. Denver Broncos NFL Pick Prediction 12/21/2025 by Tony T.

Jaguars vs. Broncos Injuries

Jacksonville and Denver starters on offense and defense are healthy. Jacksonville has an injury advantage based on the Chao ratings by +3.50 based on Broncos players on IR. Jaguars offense and defense has high ratings in the low 90s.

Recent Box Score Key Stats

Jaguars at Broncos 4PM ET—Jacksonville improved to 10-4 following their 48-20 home victory against NY Jets. Jaguars had a good passing performance and rushed for 108 yards for 4 yards per run. On defense they limited the Jets through the air and allowed 130 yards rushing for 4.1 yards per run. Trevor Lawrence completed 20 of 32 for 330 yards and five touchdowns. Denver is 12-2 with their 34-26 home victory against Green Bay. Broncos had a good passing game and rushed for 89 yards for 2.9 yards per run. On defense they allowed 5.8 yards per rush with 247 yards passing for 6.2 yards per pass attempt. Bo Nix hit 23 of 34 for 302 yards and four touchdowns.