San Francisco 49ers vs. Indianapolis Colts NFL Pick Prediction 12/22/2025 by Tony T.
San Francisco receiver Pearsall is out. On defense a corner is out. Indianapolis left tackle and quarterback Daniel Jones are out. On defense a corner is out. San Francisco has a slight injury advantage based on the Chao ratings by +1.70. SF defense has the lowest health rating at 70.2 based on their players on IR.