San Francisco 49ers vs. Detroit Lions Pick Prediction 9/12/2021 by Tony T.
49ers at Lions—NFL pick is San Francisco 49ers and Detroit Lions to play under the total of 46 points. San Francisco built a strong defense, but they were hit very hard with injuries. Back healthy are defensive ends Nick Bosa and Dee Ford. Healthy is the 49ers offensive line and running back positions which greatly aids Jimmy Garoppolo in the passing game. Detroit switches from Matthew Stafford to Jared Goff. The former Ram didn't live up to expectations in Los Angeles as he struggled in the pocket. Goff doesn't handle pressure well and the 49ers know that. Detroit will have trouble scoring. 49ers build lead and drain clock with run and short passes to preserve victory. Play San Francisco and Detroit under 46.