Louisville vs. Florida St Pick Prediction 9/25/2021 by Tony T.
Louisville vs. Florida St—Free pick is Florida St Seminoles -1.5. Florida St returns home still winless and desperate for a win. They dropped an overtime home defeat to Notre Dame and lost to Jacksonville St on a Hail Mary. Seminoles were able to move the football for 442 yards with 284 rushing. Quarterback McKenzie Milton is completing 63% of his passes. Louisville plays their first true road game. Cardinals were disappointing in their neutral site game against Ole Miss failing behind 17-0 at the half in a 43-24 defeat. Cardinals surrendered 569 yards to the Rebels. Louisville defense is allowing 162 rushing yards per game and 5 yards per rush. Seminoles run for 184 yards and 4.8 per attempt. Play Florida St -1.5.