Green Bay Packers vs. San Francisco 49ers Pick Prediction 9/26/2021 by Tony T.
Packers at 49ers—NFL free pick is San Francisco 49ers -3. San Francisco has had recent success at home and when healthy against the Packers by running the football. Green Bay is surrendering 4.8 yards per rush. San Francisco has taken hits to their running backs, but they do expect Trey Sermon to return. San Francisco defense coming off an impressive performance at Philadelphia holding the Eagles to 11 points in a back to back road spot. Packers off a short week after a Monday Night win and in a travel spot to the west coast. 49ers quarterback Jimmy Garoppolo is completing 70.9% of his passes and leading a passing attack averaging 8.9 yards per attempt. Play San Francisco -3.