San Francisco 49ers vs. Tennessee Titans NFL Pick Prediction 12/23/2021 by Tony T.
49ers at Titans—Titans are without two offensive lineman and an inside linebacker. 49ers running back Elijah Mitchell is listed as out. They have a linebacker out and questionable. Tennessee defense trending well past three games as they are holding opponents to 251 yards, 3 yards per rush and 6.2 yards per pass attempt. In that period, they are running for 191 yards and 5 yards per rush. These Thursday night games are a disadvantage for the traveling team as they have less preparation time. 49ers offense is 20th on third down. Play Tennessee +3.5.