Indianapolis Colts vs. Arizona Cardinals NFL Pick Prediction 12/25/2021 by Tony T.
Colts at Cardinals—Colts will be without their starting guard and center. Cardinals running back James Conner is leaning towards playing. Wide out DeAndre Hopkins on IR and Rondale Moore questionable. Their starting center out and backup questionable. Could be a third string at that position. On defense a tackle is out. Indianapolis has won four of five following the 27-17 home win to New England Patriots.